Olmesartan medoxomil is an antihypertensive agent which belongs to the class of medicines called angiotensin II receptor antagonists. It acts rapidly to lower high blood pressure. One of the major problems with this drug is its low solubility in biological fluids, which results into poor bioavailability after oral administration. The present study is an attempt to enhance the dissolution rate of olmesartan medoxomil by solvent evaporation techniques using olmesartan medoxomil and β-cyclodextrine and Hydroxypropyl-β-cyclodextrin as carrier in the ratios of 1:1, 1:2, 1:3 and 1:4 respectively. The prepared solid dispersions were characterized for bulk density, tapped density, Carr’s Index, Hausner’s ratio, angle of repose, saturation solubility study, drug content, drug dissolution, hardness, friability, thickness. The solvent evaporation techniques were found to be efficient method to obtained good yield solid dispersions with good flow properties. The drug content was found in the ranges of 99.2±0.28 to 100.8±0.19 %. Dissolution study revealed that there is marked enhancement in the dissolution rate of olmesartan medoxomil from all the solid dispersions when compared to pure olmesartan medoxomil itself. From the in-vitro drug release profile, it can be seen that formulation F8 (1:4 ratio of drug: HP β-cyclodextrine, prepared by solvent evaporation technique) shows higher dissolution rate compared with other formulations.
Loading....